Nature

World’s first personalized CRISPR therapy given to baby with genetic disease

Treatment seems to have been effective, but it is not clear whether such bespoke therapies can be widely applied

Can NIH-funded research on racism and health survive Trump’s cuts?

The US administration has cancelled ‘DEI grants’ without defining DEI, leaving health-equity researchers in the dark.

Smriti Mallapaty
News16 May 2025
US brain drain: Nature’s guide to the initiatives drawing scientists abroad

In response to US turmoil, premier establishments such as the European Research Council have sweetened incentives to attract talent.

Nisha Gaind
Rachel Fieldhouse
Giorgia Guglielmi
News16 May 2025
A human-specific enhancer fine-tunes radial glia potency and corticogenesis

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence between cortical regions through amplified WNT signalling.

Jing Liu
Federica Mosti
Debra L. Silver
Article14 May 2025
Daily briefing: These award-winning photos show scientists at work

The best of scientists’ photos from the field. Plus, researchers are split about whether it’s OK for AI to write science papers and bad philosophy is stopping progress in physics, says Carlo Rovelli.

Flora Graham
Nature Briefing14 May 2025
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Current Issue15 May 2025

News & Comment

‘Minimalist’ quantum computer simulates movements of molecules

A single trapped ytterbium ion can be used to simulate complex changes in the energy levels of organic molecules interacting with light.

Davide Castelvecchi

News16 May 2025
Can NIH-funded research on racism and health survive Trump’s cuts?
Smriti Mallapaty

News16 May 2025
US brain drain: Nature’s guide to the initiatives drawing scientists abroad
Nisha Gaind
Rachel Fieldhouse
Giorgia Guglielmi

News16 May 2025
Can AI help us talk to dolphins? The race is now on
Mariana Lenharo

News16 May 2025
Stem cells coaxed into most advanced amniotic sacs ever grown in the lab
Smriti Mallapaty

News15 May 2025
World’s first personalized CRISPR therapy given to baby with genetic disease
Heidi Ledford

News15 May 2025
Powerful CRISPR system inserts whole gene into human DNA
Elie Dolgin

News15 May 2025

Latest Reviews & Analysis

- Immune control of metastatic cancer at the edge of the central nervous system
  
  Leptomeningeal metastasis is a deadly consequence of cancer that creates an unusually inflamed environment around the brain and spinal cord. One of the inflammatory signalling molecules found in cerebrospinal fluid, interferon-γ, induces an antitumour immune response through an unexpected series of cell–cell interactions.
  
  Research Briefing14 May 2025
- Black hole fly-by modelled with landmark precision
  
  A prediction of the gravitational waves produced by interacting black holes achieves high precision and demonstrates the link between general relativity and geometry.
  
  Zhengwen Liu
  
  News & Views14 May 2025
- Black hole flings out clumps of gas
  
  Measurements of wind in a luminous galactic core reveal dense pockets of gas — a finding that calls for a rethink of how black holes interact with their host galaxies.
  
  Manuela Bischetti
  
  News & Views14 May 2025
- Track record: unexpectedly early reptile claw prints found
  
  Fossil evidence points to an earlier-than-expected timeline for when reptiles, members of the four-limbed group of animals called tetrapods, began to evolve.
  
  Stuart S. Sumida
  
  News & Views14 May 2025
- Genomes from a four-generation family reveal the rate of new mutations
  
  The rate at which mutations arise can be estimated by studying multigenerational human families. Reference genomes have been assembled for 28 people from four generations of the same family. This publicly available resource provides insight into the mechanisms that underlie mutations in the most complex regions of the genome.
  
  Research Briefing14 May 2025
- Marsupial embryos lack the epigenetic reset seen in placental mammals
  
  Research Briefing14 May 2025
- Earth’s climatic past illuminates future South Asian monsoon patterns
  
  Francesco S. R. Pausata
  Thejna Tharammal
  
  News & Views14 May 2025
- Where do comets come from?
  
  News & Views13 May 2025
- North America’s birds are declining where they should be thriving
  
  Holly Smith
  
  News & Views12 May 2025

Latest Research articles

Ku limits RNA-induced innate immunity to allow Alu-expansion in primates

Yimeng Zhu
Angelina Li
Shan Zha
Article15 May 2025
Structured ionized winds shooting out from a quasar at relativistic speeds

Observations of a luminous quasar from the high-resolution spectrometer Resolve aboard XRISM revealed highly inhomogeneous wind structure outflowing from a supermassive black hole, which probably consists of up to a million clumps.

Marc Audard
Hisamitsu Awaki
Yerong Xu
Article14 May 2025
Past warm intervals inform the future South Asian summer monsoon

Proxy records and climate simulations show that in past warm intervals, the South Asian summer monsoon was characterized by an increase in monsoon rainfall, and weakening and strengthening of different parts of the monsoon circulation, consistent with future projections.

Linqiang He
Tianjun Zhou
Zhun Guo
Article14 May 2025
Exploring pathways for world development within planetary boundaries

Current trends imply that we will transgress most of the planetary boundaries by 2050; however, ambitious, urgent and universal action to ameliorate climate change and increase resource efficiency can effectively reduce the degree of transgression.

Detlef P. van Vuuren
Jonathan C. Doelman
Willem-Jan van Zeist
ArticleOpen Access14 May 2025
Radiation-induced amphiregulin drives tumour metastasis

Radiotherapy induces expression of the EGFR ligand amphiregulin, which promotes metastasis growth at remote sites in mouse models and human patients by shifting myeloid cells towards an immunosuppressive state.

András Piffkó
Kaiting Yang
Ralph R. Weichselbaum
Article14 May 2025

Since US President Donald Trump took office in January 2025, his team has made major changes to the federal government that have disrupted research and research institutions in the United States and beyond.

Collection 26 Feb 2025

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Postdoctoral Fellow in Bioinformatics

Postdoctoral research position in bioinformatics focused on studying the somatic genetic mechanisms of neurological diseases.

Longwood Medical Area, Boston, Massachusetts

Brigham and Women's Hospital/Harvard Medical School
HORIZON MSCA COFUND - 13 Fully Funded PhD Positions in Chronic Inflammatory Disease Research: MAP-ID

13 fully funded PhD positions within the MAP-ID (Multilevel Approaches to Understanding Chronic Inflammatory Diseases)

Kraków (PL)

Jagiellonian University
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State Key Laboratory of Materials-Oriented Chemical Engineering in the field of materials-oriented chemical engineering.

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Tenure Track Assistant Professor toward Associate Professor in Digital pharmacy

UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, ...

Lausanne, Canton of Vaud (CH)

University of Lausanne (UNIL)
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The Institute for Infection Prevention and Control (IPC, Head Prof. Dr. Philipp Henneke) is looking for a Bioinformatician (m/f/d, PhD).

Freiburg im Breisgau, Baden-Württemberg (DE)

University Hospital Freiburg

World’s first personalized CRISPR therapy given to baby with genetic disease

Can NIH-funded research on racism and health survive Trump’s cuts?

US brain drain: Nature’s guide to the initiatives drawing scientists abroad

A human-specific enhancer fine-tunes radial glia potency and corticogenesis

Daily briefing: These award-winning photos show scientists at work

News & Comment

‘Minimalist’ quantum computer simulates movements of molecules

Can NIH-funded research on racism and health survive Trump’s cuts?

US brain drain: Nature’s guide to the initiatives drawing scientists abroad

Can AI help us talk to dolphins? The race is now on

Stem cells coaxed into most advanced amniotic sacs ever grown in the lab

World’s first personalized CRISPR therapy given to baby with genetic disease

Powerful CRISPR system inserts whole gene into human DNA

Latest Reviews & Analysis

Immune control of metastatic cancer at the edge of the central nervous system

Black hole fly-by modelled with landmark precision

Black hole flings out clumps of gas

Track record: unexpectedly early reptile claw prints found

Genomes from a four-generation family reveal the rate of new mutations

Marsupial embryos lack the epigenetic reset seen in placental mammals

Earth’s climatic past illuminates future South Asian monsoon patterns

Where do comets come from?

North America’s birds are declining where they should be thriving

Latest Research articles

Ku limits RNA-induced innate immunity to allow Alu-expansion in primates

Structured ionized winds shooting out from a quasar at relativistic speeds

Past warm intervals inform the future South Asian summer monsoon

Exploring pathways for world development within planetary boundaries

Radiation-induced amphiregulin drives tumour metastasis

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How Trump 2.0 is reshaping science

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Science jobs

Postdoctoral Fellow in Bioinformatics

HORIZON MSCA COFUND - 13 Fully Funded PhD Positions in Chronic Inflammatory Disease Research: MAP-ID

Recruitment of Overseas Outstanding Young Scholars

Tenure Track Assistant Professor toward Associate Professor in Digital pharmacy

Bioinformatician (m/f/d, PhD)

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Earliest amniote tracks recalibrate the timeline of tetrapod evolution

Global emergence of unprecedented lifetime exposure to climate extremes

Chicago Archaeopteryx informs on the early evolution of the avian bauplan

Migraine drug is first to tackle debilitating early symptoms

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